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Now, let’s discuss the targeted therapy agents that are used in the treatment of metastatic melanoma. As mentioned earlier, 3 targeted therapies are currently approved by the FDA for the treatment of metastaic melanoma. All 3 of these agents target the RAS/BRAF/MEK signal transduction pathway. Debrafenib (Tafinlar) and vemurafenib (Zelboraf) inhibit the activity of BRAF, while trametinib (Mekinist) inhibits the activity of MEK. This lesson focuses on the features of each of these agents.